Alternatively, we cannot discount the possibility that high-grade ovarian cancer cells could release more chemoattractants or pro-inflammatory factors such as chromatin-binding protein high mobility group B1 (HMGB1) [65] and calreticulin (CRT) [66] into the surrounding tissues to attract more monocytes/microphages to the cancer tissue [67]. This evidence concerns the gene HMGB1 and cancer.