Pointing to factors independent from RIPK3 that additionally regulate the resistance of tumor cells against programmed necrosis, MKN-28 cells expressed similar levels of RIPK3 as Colo357 or Panc89 cells but were resistant to both TRAIL/zVAD/CHX and TNF/zVAD/CHX. The gene discussed is TNFSF10; the disease is neoplasm.