TNFSF10 and neoplasm: In a complementing experiment, we found that downregulation of RIPK3 by RNA interference in U-937 and HT-29 cells as two sensitive tumor cell lines that express relatively high levels of RIPK3 significantly blocked TRAIL/zVAD/CHX- as well as TNF/zVAD/CHX-induced necrotic killing (Figure 3d).