At four weeks after infarction, higher LVEF and FS were observed in the HIF-1α + MSCs group compared with the HIF-1α (P <0.05), HIF-1α-MSCs (P <0.05), MSCs (P <0.01) and Control groups (P <0.01), indicating that the combined HIF-1α and MSCs intramyocardial injection can significantly improve the cardiac function. This evidence concerns the gene HIF1A and infarction.