RIGI and hepatocellular carcinoma: Also, expression of adaptor proteins TRIF and MyD88 (TLR adaptor proteins) and of IPS-1 (RIG-I/MDA5 adaptor protein) in human hepatoma cells was enough to limit HBV replication by reducing the steady-state levels of viral mRNAs, in a manner dependent on NF-κB transcription factor [19].