SMAD3 and ovarian carcinoma: A. In gastric cancer [76]: six miRNA-regulated protein networks are identified in gastric cancer based on the human PPI network; it is suggested that miR-148a may resist tumor extension. B. In human ovarian cancer [77]: six miRNAs (hsa-mir-20a, hsa-mir-24-2, hsa-mir-34a, hsa-mir-21, hsamir-17 and hsa-mir-hsa-mir-155) and six TFs (BRCA1, SP1, ESR1, SMAD3, PO2F1 and TFE2) play key roles in ovarian cancer progression. C. In aging-related diseases [78]: 35 genes related to diseases associated with aging were identified.