Cancer site (risk up to age 70)Colon (40–80% MLH1, MSH2)(10–22% MSH6, PMS2)Endometrium (25–60% MLH1, MSH2)(15–26% MSH6, PMS2)Increased cancer risks: stomach, ovarian, hepatobilliary tract, urinary tract, small bowel, others. The gene discussed is MLH1; the disease is cancer.