SOAT1 and inflammation: However, in DSS-induced colitis model, it will be fruitful to understand the effect of arginine or glutamine supplementation on other colonic signaling pathways, such as signal transducer and activator of transcription (STAT), activating protein-1 (AP-1), and peroxisome proliferator-activated receptor-γ (PPARγ), which play central role in intestinal inflammation [7].