Mutations predicted to create p16-14ARF chimeric proteins have been documented in many primary cancers [11] and [24] including familial melanoma [25], squamous cell carcinoma of the skin [26] and squamous cell carcinoma of the esophagus [13] and therefore such mutations represent an important avenue of cancer research. Here, CDKN2A is linked to esophageal squamous cell carcinoma.