The TMP-mediated down-regulation of CXCR4 in cerebral neurocytes inhibits somatic Ca2+ increase, decreases glutamate release from glial cells, and effectively inhibits the viability and migration of cultured C6 glioma cells, which induces neural protection and the suppression of C6 gliomas. The gene discussed is CXCR4; the disease is central nervous system cancer.