Since, the majority of the IgG Ab response to ID1-ID2a was not pregnancy-associated, but Ab levels to the 3D7 strain of ID1-ID2a were slightly higher in MG compared to males in Ngali II, we sought to determine if: 1) ID1-ID2a induced a pregnancy-associated IgM response without isotype-switching to IgG, i.e., was a weak immunogen, 2) Ab avidity to ID1-ID2a differed between MG and males, and 3) MG have Ab to epitopes in other N-terminal DBL domain constructs that are not present in males. Here, CD40LG is linked to myasthenia gravis.