Activation of the cell death signal JNK (Figure 3A) and inhibition of the cell survival signals, p-PI3K, p-AKT, and p-ERK (Figure 3A and B) were also observed in β-lapachone-mediated lung cancer cell death, showing that the MAP kinase signaling pathway is involved in the anticancer effect of β-lapachone. Here, MAPK8 is linked to lung cancer.