The funnel plot for studies assessing the effect of marine-derived n-3 PUFAs supplementation on IL-6 in subjects with chronic non-autoimmune disease showed a slight asymmetry, indicating that considerable publication bias existed (Figure S3); trim-and-fill test suggested that 7 studies needed to be trimmed to make the funnel symmetric, and after the addition of 7 studies, the pooled effect size on IL-6 became −0.35 (95% CI, −0.49 to −0.20) and still remained significant (p = 0.000); the corresponding percentage of change (in geometric mean) for IL-6 was −29.53% (95% CI, −38.74% to −18.13%). The gene discussed is IL6; the disease is autoimmune disease.