Therefore, we conducted a meta-analysis to systematically review the effect of marine-derived n-3 PUFAs from different sources (supplementation or dietary intake) on fasting blood levels of TNF-α, IL-6 and CRP in three groups of subjects (healthy subjects, subjects with chronic non-autoimmune disease or subjects with chronic autoimmune disease), and to obtain a pooled estimate of effect size. The gene discussed is TNF; the disease is autoimmune disease.