Secondly, a significant heterogeneity was observed in the three meta-analyses assessing the effect of marine-derived n-3 PUFAs supplementation on CRP, IL-6 and TNF-α in subjects with chronic non-autoimmune disease as well as the meta-analysis evaluating the effect of marine-derived n-3 PUFAs supplementation on IL-6 in healthy subjects. This evidence concerns the gene IL6 and autoimmune disease.