To better understand the role of antibody response in the pathology of schistosomiasis, we first quantified IgE concentration and then evaluated the association of parasite (SEA and SWAP)-reactive IgG and IgE with the clinical form of the disease, which was defined based on clinical and ultrasound examination of S. mansoni-infected patients selected from the endemic area of Corrego do Choro, Padre Paraíso city, Minas Gerais. The gene discussed is IGHE; the disease is schistosomiasis.