Additionally, the MMP-1.1 2G allele may be implicated in the differentiation of gastric cancer, lymph node metastasis of breast cancer, in decreasing the age of onset in male smokers of lung cancer and tumors with infiltrative growth, and in lymph node metastases in colorectal cancer [21], [30], [42], [43]. Here, MMP11 is linked to metastatic malignant neoplasm in the lymph nodes.