In the present study, we conducted a hospital-based case-control study to explore the association of the MMP-1 gene promoter SNPs [−1607 1G/2G (rs1799750) (MMP-1.1), −519A/G (rs1144393) (MMP-1.2), −422T/A (rs475007) (MMP-1.3), −340C/T (rs514921) (MMP-1.4), and −320C/T (rs494379) (MMP-1.5)] and their haplotypes with the risk of gastric cancer development in an eastern Indian population. Here, MMP11 is linked to gastric cancer.