In order to investigate the impact of MMP-1 promoter polymorphisms on the gene function, we compared serum MMP-1 level by serum ELISA in patients having lower stomach cancer with combined risk haplotypes (having at least any one risk allele) vs. upper stomach cancer with the reference haplotype (1G-A-A-T-T). This evidence concerns the gene MMP1 and gastric neoplasm.