MMP1 and melanoma: Functional effects of these polymorphisms on the MMP-1 gene promoter activity were assessed in cell lines of melanoma (A2058 and A375), breast cancer (MCF7 and MDA-MB-231), lung cancer (A549 and H69), and colorectal cancer (HT-29, SW-620) by comparing the promoter strengths of the 10 most common haplotypes derived from these polymorphisms [24].