Even though the two loci have opposite effects on the production of cytokines, the overall production of IL6, IFN-γ and IL-12 in response to Salmonella infection in vivo by Ity3 congenic was significantly lower compared to the Ity strain suggesting the existence of interaction between Ity3.1 and Ity3.2. The gene discussed is IFNG; the disease is Salmonella Infections.