MTOR and pancreatic neuroendocrine tumor: Recent studies have demonstrated that phosphatidylinositol-3-kinase(PI3K)-Akt/ mammalian target of rapamycin (mTOR) pathway is also involved in Pancreatic endocrine tumors (PETs) tumorigenesis and progression [9], [10], cell survival, cell adhesion and metastasis [11], [12].