Comparison of 2B4+ and 2B4− CD8+ T cells revealed a higher frequency of CD57 (p<0.05) and lower frequency of CD62L expression (p<0.05) on 2B4+CD8+ T cells in paired samples from ATLL subjects as shown in Figure 2 C, D). This evidence concerns the gene CD8A and adult T-cell leukemia/lymphoma.