In the naïve compartment, 2B4+CD8+T cells were significantly higher in uninfected healthy donors (HD) compared to ATLL and AC (ATLL 0.59±0.53; AC 0.38±0.38; HD 8.22±7.2; p<0.05) possibly suggesting ongoing activation in response to exposure to viral infection. This evidence concerns the gene CD8A and adult T-cell leukemia/lymphoma.