However, another study [43] suggested an activating role for 2B4 in HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP), correlating with SAP levels, which was higher in patients with HAM/TSP compared to asymptomatic HTLV-1 infected individuals, and lowest in uninfected controls. The gene discussed is SH2D1A; the disease is Myelopathy.