Comparing 2B4 expression on HTLV-1 specific CD8+ T cells relative to total CD8+ T cells in matched ATLL and ACs subjects, we observed a significant up-regulation of 2B4 expression in both groups as shown in Figure 4 (ATLL: 62.2±21.6 vs. 75.2±23.1; AC: 65.3±16.2 vs. 86.9±13.7; p<0.05). The gene discussed is CD8A; the disease is adult T-cell leukemia/lymphoma.