The UAP1 gene is located between UHMK1 and DDR2, thus structural rearrangement between UHMK1 and DDR2 is likely disruptive to the normal function of UAP1. The UAP1 protein is predicted to interact with glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase (GNE) [51], [52], a kinase regulating the biosynthesis of sialic acids which play a critical role in cell adhesion, signal transduction and tumor metastasis [53]. This evidence concerns the gene GNE and neoplasm.