Considering the final endpoint, using Sanger sequencing we detected a KRAS mutation in 42.1% of adenocarcinomatous and pre-neoplastic lesions (in 40% of PDAC, 41.7% of IPMNs and in the 50% of inoperable neoplasms), while no KRAS mutations were observed in not adenocarcinomatous or in benign lesions (Table 2). This evidence concerns the gene KRAS and neoplasm.