HIF1A and prostate neoplasm: In this study, we have identified MRV as one such potential therapy by demonstrating that MRV replicates to high levels in prostate tumor cells grown in hypoxic environments (Fig. 1), induces massive downregulation of the HIF-1α protein via degradation and translational inhibition (Figs. 2, 3), and leads to apoptosis of the cells (Fig. 6).