Addition of MG132 to the infected samples from 8–12 h p.i., was able to rescue HIF-1α to levels similar to those seen in uninfected cells (Fig. 3A); suggesting that MRV infection induces proteasome-mediated degradation of HIF-1α in hypoxic prostate tumor cells at early times p.i. This evidence concerns the gene HIF1A and prostate neoplasm.