NFKB1 and colitis: CK and BBR have demonstrated potent anti-inflammation effects in vivo. It has been reported that in peritoneal macrophages and RAW264.7 cell lines, BBR can down-regulate NF-κB pathway that mediate pro-inflammatory cytokines production, and contribute to relieve the colitis injury, which suggests that BBR has influence on regulating the innate immune responses.