Lin et al (62) transfected PC3 cells with mir-146a, a microRNA found to be downregulated in hormone-refractory prostate tumors, which targets ROCK1. Suppression of ROCK1 in these prostate cancer cells reduced cell proliferation, invasion capacity and their adhesion potential to bone marrow endothelial cells in vitro. Here, ROCK1 is linked to prostate carcinoma.