We first investigated the effect of novel RRs [VN/14-1 (parent RRs), VN/66-1, VNLG-145, −146, −147, −148, −152, −153] and Mnk inhibitors (CGP57380 and cercosporamide) on the growth and proliferation of triple negative (MDA-MB-231 and MDA-MB-468) and Her-2 overexpressing (SKBR-3) breast cancer cells by MTT and colony formation assays. The gene discussed is ERBB2; the disease is breast carcinoma.