Chromosomal aberrations harboring a fusion product of ERG to form FUS/TLS-ERG in acute myeloid leukemia (AML)[3], ERG-EWS in Ewing's sarcoma[4], or TMPRSS2-ERG[5,6] in prostate cancers are predictive of poor prognosis. The gene discussed is TMPRSS2; the disease is prostate cancer.