ERG-induced gene signature positively correlated with three invasive and metastatic cancer mRNA expression dataseis: 1) Grasso dataset prostate tissues habouring ERG rearrangement versus no ERG rearrangement[29], 2) Grasso dataset of prostate carcinoma tissues versus normal prostate gland[29] and 3) Stickeler dataset of invasive breast cancer patients treated with a standard regimen of chemotherapy assessing post-chemotherapy versus pretreatment changes[30] (Supplement Figure 1A–D and Supplement Table 1). The gene discussed is ERG; the disease is metastatic malignant neoplasm.