In this context, our study, which is based on a very large and unselected cohort on 1421 CRC cohorts using this next generation of specific rabbit monoclonal antibody, demonstrates the high prevalence of MYC over-expression in CRCs, and more importantly, the potential role of myc as a powerful prognostic biomarker in CRCs. This evidence concerns the gene MYC and colorectal carcinoma.