In the full multivariable model, the adjusted effect of MYC over-expression on overall survival became insignificant [hazard ratio = 0.91 (95%CI = 0.69–1.20), p = 0.52] due to the dominant effect of age at diagnosis, tumor stage and lymphovascular space invasion status and the MMR deficient/BRAFV600E mutant IHC phenotype on survival (Table 3). The gene discussed is MRC1; the disease is neoplasm.