LGALS1 and cancer: Cancer cells secrete collagenase and then disassemble collagen molecules to induce invasion and metastasis.40 In contrast, collagen can inhibit cancer cells and fibroblast motility by inhibiting MMP secretion and expression in adjacent cells.16, 41 Thus, it is possible that Gal-1-reduced COL-3/-5 stimulates human UCB-MSC motility.