MAPT and supranuclear palsy, progressive, 1: Tau pathology has been described in white matter of PSP brains, with overexpression of 4R-tau protein isoforms in the sub-cortical regions and brain stem (Zhukareva et al., 2006), and vacuolation with glial inclusions as a consequence of adjacent gray cellular loss and downstream effects of tau pathology, respectively (Armstrong, 2013).