In addition to the established role of tau, the genes implicated by these associations provide tantalizing suggestions about the cellular pathways and processes that could be affected in PSP, including intracellular vesicular trafficking, central nervous system (CNS) myelination and the endoplasmic reticulum (ER)-mediated cellular response to stress, and abnormally unfolded proteins (Höglinger et al., 2011). This evidence concerns the gene MAPT and supranuclear palsy, progressive, 1.