Elucidation of the possible functional basis of the H1 haplotype association with PSP and corticobasal degeneration (CBD) has led to suggestions of allele-specific differences in transcription and alternative splicing of MAPT; both PSP and CBD tau pathology is predominantly 4-repeat tau (4R-tau), that is, consisting of tau protein isoforms with 4 microtubule-binding domains as a result of splicing of MAPT exon 10 (Caffrey et al., 2006, 2008; Chambers et al., 1999; Luk et al., 2010; Majounie et al., 2013; Takanashi et al., 2002; Trabzuni et al., 2012). This evidence concerns the gene MAPT and supranuclear palsy, progressive, 1.