Sequencing of STX6 (Table 1, Fig. 2A) revealed a novel missense variant in exon 8 in a single PSP case causing a Cys236Gly substitution (GenBank accession: CAG46671.1) with a PolyPhen-2 score (Adzhubei et al., 2010) of 0.999 (probably damaging; sensitivity: 0.14; specificity: 0.99). Here, STX6 is linked to supranuclear palsy, progressive, 1.