MR1 and supranuclear palsy, progressive, 1: MR1 screening identified one missense change rs41268456; Arg31His in the conserved extracellular α1 ligand-binding domain (Abos et al., 2011) and has a PolyPhen score of 0.996 (probably damaging) but is very rare with a single heterozygote in the PSP cases and comparable MAFs for PSP (0.007) and 1000 Genomes controls (0.004).