To substantiate the beneficial and therapeutic role of Hmox1 and its metabolites in preeclampsia, the same group demonstrated that the pharmacological induction of Hmox1 in this rat model attenuated the elevation in blood pressure, restored the angiogenic balance, and also reduced placental oxidative stress in the ischemic placenta (George et al., 2011). Here, HMOX1 is linked to preeclampsia.