Subgroup analyses showed that, among 19 patients with suspected FH in whom no previous candidate gene sequencing had been performed, 8 (42.1%) carried heterozygous rare variants in candidate FH genes, including 5 in LDLR, 3 in APOB, and 1 in LDLRAP1 (supplementary Table V). This evidence concerns the gene LDLRAP1 and familial hyperaldosteronism.