Indeed, we detected strong expression of SPRR2, SLPI, EPGN and of the classical NRF2 target NQO1 in the epidermis and cyst epithelium of MADISH patients, with particularly strong staining of SPRR2, SLPI, and NQO1 in differentiated keratinocytes (Fig 7B–E). The gene discussed is NQO1; the disease is cyst.