Slpi, which inhibits kallikrein 7, a protease required for corneodesmosome cleavage (Franzke et al, 1996), was significantly upreg-ulated in the epidermis of K5cre-CMVcaNrf2 transgenic mice, leading to reduced desquamation and consequently hyperkeratosis (Schäfer et al, 2012). Here, SLPI is linked to Hyperkeratosis.