In agreement with our in vitro data, examination of human PDAC (whole tissue sections rather than TMAs) showed a significant increase in the percentage of fibroblasts demonstrating nuclear FGFR1 and FGF2 at the invasive front (invading into adipose tissue, duodenum or normal pancreatic tissue) as compared to those within the centre of the tumour (Fig 8). This evidence concerns the gene FGF2 and neoplasm.