Furthermore, a subsequent study by the same group showed that the conditional knock-out of the mitochondrial transcription factor A, Tfam, specifically within dopaminergic neurons causes a reduction in mtDNA expression and importantly progressive parkinsonism within the mice, dopaminergic neuron loss and the accumulation of protein inclusions (Ekstrand et al., 2007). The gene discussed is TFAM; the disease is Parkinsonism.