Mice with 7 days-established peritoneal ID8 ovarian cancer were treatedintraperitoneally (i.p.)with either control, anti-PD-1, anti-GITR oranti-PD-1/GITR monoclonal antibody (mAb) and their survival was evaluated; thephenotype and function of tumor-associated immune cells in peritoneal cavity oftreated mice was analyzed by flow cytometry, and systemic antigen-specific immuneresponse was evaluated by ELISA and cytotoxicity assay. The gene discussed is TNFRSF18; the disease is ovarian cancer.