The insensitivity of ID8 ovarian cancer to treatment ofsingle anti-PD-1 or anti-GITR mAb is in part due to lack of expression of PD-1 ligandsPD-L1/2 or GITR ligand GITRL since ligand expression on the tumor has been reported tobe correlated with the response to these mAbs [19,37]. The gene discussed is TNFSF18; the disease is ovarian cancer.