As adiponectin is known to possess insulin-sensitizing, anti-diabetic properties and reduced circulating levels are also observed in type 2 diabetes mellitus [24], IR might possibly be a link between lower adiponectin level and development of polycystic ovarian syndrome; however, whether low adiponectin is a cause or a consequence of IR in PCOS remains debated. This evidence concerns the gene INS and polycystic ovary syndrome.