In our study, the combinatory effect of the Hif1a+/- genotype and diabetes was detected in the expression of Gata2, Ctss, and Tfgbr1. The transcriptional factor GATA2 cooperates with HIF1-α and complements HIF-1 transcriptional regulation of pro-inflammatory genes in endothelial cells[39,40]. Here, CTSS is linked to diabetes mellitus.