Furthermore, 100% (13/13) of the examined sentinel lymph nodes in mice bearing VEGF-D overexpressing xenografts contain tumor cells, whereas the rate of metastasis to sentinel lymph node was only 62.5% (5/8) and 60% (6/10) in mice bearing SKOV3 or SKOV3/pcDNA xenografts, respectively (P < 0.05 for both; Figure 4H). This evidence concerns the gene VEGFD and neoplasm.