The main cytokines present in the inflammatory tumor microenvironment include inflammatory cytokines such as tumor necrosis factor α (TNF-α) [6], interferon-gamma (IFN-γ) [7], interleukin-6 (IL-6) [8,9], IL-8 [8], IL-1, and transforming growth factor-beta (TGF-β); growth factors such as hepatocyte growth factor (HGF), platelet-derived growth factor (PDGF), and vascular endothelial growth factor (VEGF); chemokines such as stromal cell-derived factor-1 (SDF-1) [10]; and other factors such as matrix metalloproteinases. The gene discussed is TNF; the disease is neoplasm.