The results revealed that the significant prognostic factors were histological grade (Figure6D, P = 0.004), lymph node metastasis (Figure6E, P = 0.004), E-cadherin (Figure6K, P = 0.015) and DNMT1 methylation (Figure6L, P = 0.016). The gene discussed is CDH1; the disease is metastatic malignant neoplasm in the lymph nodes.