PAK4 and melanoma: Interestingly, COSMIC reports a Ser99Phe mutation of PAK7 in a case of malignant melanoma, and ANIA predicts Ser99 as a candidate ‘lynchpin’ 14-3-3 binding phosphosite, which is conserved in human PAK4, 6 and 7, as well as the Branchiostoma and Ciona pro-orthologues.