IGFBP3 and neoplasm: Given that increases in insulin-like growth factor 1 (IGF1) and decreases in IGF-binding protein 3 (IGFBP3) are associated with tumor formation and metastasis, one study looked at the effects of resveratrol supplementation (0.5, 1.0, 2.5, and 5 g/day for 29 days; n=10–12/dose) on circulating levels of these proteins (Brown et al. 2010).