On the other hand, no significant differences in gene expression in tumor related to matched non-tumor lung tissue were found between AdC and LCC samples, except for the activity of TNF and CXCR3. Based on these results, the analyzed genes seem to be involved in the process of NSCLC evolution, especially in the case of SqCC of the lung, but further examinations are necessary to clarify their contribution to tumor growth and progression. Here, TNF is linked to non-small cell lung carcinoma.