Our previous studies have shown that LMP1 can activate cyclin D1 gene expression[38], upregulate the promoter activity of cyclin D1 by inducing c-Jun/Jun B heterodimers[39] and via EGFR transcriptional activity as well as transcriptional intermediary factor 2 (TIF2) interaction[40] in NPC cell lines. Here, EGFR is linked to nasopharyngeal carcinoma.