Nuclear EGFR-targeted genes including cyclin D1[54,64], iNOS, B-Myb, Aurora A and COX-2, have been reported, yet these studies did not support cyclin D1 as the target gene co-regulated by EGFR and other transcription factors after the infection of EBV, such as in the work of EGFR and STAT3 co-affecting on iNOS and STAT1 in breast cancer[31,57]. This evidence concerns the gene STAT3 and breast cancer.