To our knowledge, there is very little information about CaM levels in AD brain; however, impaired CaM-dependent activation of CaMKII or phosphoinositide-3 kinase/Akt has also been described in AD brain [47,48], and therefore it is tempting to speculate that changes in CaM levels in AD lymphoblasts may be another peripheral sign of the disease. Here, AKT1 is linked to Alzheimer disease.