Furthermore, the abnormal brain vascular constriction and vasodilation caused by an imbalance of ET-1 and CGRP expression and the increase in brain vascular permeability induced by abnormal expression of VCAM-1, ICAM-1 and P-selectin participate in CVD complications in T2DM by ETD, which provides new evidence for preventing the related CVD in diabetes. The gene discussed is EDN1; the disease is diabetes mellitus.