Second, our results contribute to a growing body of evidence indicating that the ETD contributes to CVD in T2DM by an imbalance of ET-1, CGRP, VCAM-1, ICAM-1 and P-selectin expression, because the imbalance of these endothelial function-associated factors contributes to ETD responses. The gene discussed is ICAM1; the disease is type 2 diabetes mellitus.