Following tissue insult and nerve injury, TLRs (such as TLR2, TLR3, and TLR4) induce the activation of microglia and astrocytes and the production of the proinflammatory cytokines in the spinal cord, leading to the development and maintenance of inflammatory pain (e.g. serum-transferred arthritis) and neuropathic pain [3,41,42]. This evidence concerns the gene TLR3 and arthritic joint disease.