IGFBP3 and metabolic syndrome: Several metabolic syndrome components are associated with genes within and around these regions including peroxisome proliferator-activated receptor gamma (Pparg), energy homeostasis (Enho), insulin-like growth factor binding protein 3 (Igfbp3), palmitoyl-protein thioesterase 1 (Ppt1), and sortilin 1 (Sort1).