A recent study with POAG and PXG patients indicated that MMPs/TIMPs ratios from TMs pecimens are decreased in PXG, while in samples of POAG eyes, the MMP-1/TIMP-1 ratio and the total MMP1 + 2 + 3 + 9/total TIMP1 + 2 + 3ratio were increased when compared to PXG eyes [33]. Here, TIMP1 is linked to open-angle glaucoma.