NP clearance receptors (NPRC) which was found on adipocytes, referred to as the clearance receptor binds ANP and BNP to remove them from circulation, and elevated NPRC have been demonstrated in patients with obesity, suggesting that a putative role for adipose tissue in the clearance of NPs from the circulation[40-42]. The gene discussed is NPPB; the disease is obesity due to melanocortin 4 receptor deficiency.