The pathological hallmarks of AD are amyloid plaques, containing amyloid-β peptide, derived from the transmebrane amyloid precursor protein, and neurofibrillary tangles, composed of hyperphosforylated tau protein, in the medial temporal lobe structures and cortical areas of the brain together with neuronal death and synapses loss[5,6]. The gene discussed is APP; the disease is Alzheimer disease.