To further determine the roles of K-ATP channels in resveratrol mediated protection against myocardial I/R injury, we compared myocardial infarct size in WT, Kir6.2 knockout (Kir6.2-/-) and Kir6.1 heterozygote mice (Kir6.1+/-). Here, KCNJ8 is linked to infarction.